What is cortisol, and does it change in menopause?
Short answer
- Cortisol is a stress hormone. It helps you wake up and handle challenges.
- A long-term study found that cortisol levels went up for some women during the late menopause transition.
- Hot flashes, poor sleep and life stress can all link to higher cortisol.
- Cortisol is not 'bad.' Problems come when stress never shuts off.
What to look out for
- Feeling 'tired but wired.'
- Waking up at night with a racing mind.
- Stress that feels bigger than before.
Top 3 things to act on or ask your clinician
- Ask: 'Could stress be part of my symptoms?'
- Ask: 'Is a cortisol test useful for me, or not?'
- Ask about stress support options, like counseling.
Sources for this answer
- Peer-reviewed Woods NF et al. Cortisol levels during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health Study. Menopause. 2009;16:708-18. PMID: 19322116. DOI: 10.1097/gme.0b013e318198d6b2
- Peer-reviewed Epel ES et al. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. 2000;62:623-32. PMID: 11020091. DOI: 10.1097/00006842-200009000-00005
- Peer-reviewed Stuenkel CA et al. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100:3975-4011. PMID: 26444994. DOI: 10.1210/jc.2015-2236
- Peer-reviewed The North American Menopause Society (now The Menopause Society). The 2022 hormone therapy position statement of The North American Menopause Society. Menopause. 2022;29:767-794. PMID: 35797481. DOI: 10.1097/GME.0000000000002028
- Expert commentary, not research Dr. Mary Claire Haver (OB/GYN): The New Menopause (book, Rodale, 2024)
- Expert commentary, not research Dr. Sara Gottfried on Huberman Lab: How to Optimize Female Hormone Health for Vitality & Longevity (podcast episode, Jan 2023)
- Non-clinical wellness opinion, not research Gary Brecka, The Ultimate Human, Ep. 227: Menopause: Symptoms, Hormones, Tests & Solutions (podcast episode, Dec 2025)